ceesdekker No Further a Mystery
ceesdekker No Further a Mystery
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Rotary motion of DNA rotors on nanopores. Top row: Uncooked video of your Cy5 channel of each rotor. Center row: corresponding single-particle localization success of the two finishes on the DNA rotors. The position of the present frame is marked as orange and blue dots, plus the trajectory of the 10 frames prior to The existing frame is demonstrated as solid traces.
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
‘It absolutely was only a subject of choosing up a book on mobile biology and starting to study. I'd come from a globe of extremely-substantial vacuums, cryostats and quantum phenomena, and now I was Doing the job at place temperature with molecular biology kits.
Sculpting nano-electrodes which has a transmission electron beam for electrical and geometrical characterization of nanoparticles.
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Our investigation ranges with the biophysics of DNA to artificial cells and outside of. You should have a look under on the spectrum of our existing tasks.
Many associated developments followed, exactly where our group set up distinct transistor variants including solitary-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled a number of transistors into modest evidence-of-basic principle Digital circuits.
Studying DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.
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1). The existing–voltage curves showed major modulations with gate voltage, even at space temperature, which was according to band bending in the ~0.six eV bandgap semiconducting nanotube. These knowledge also confirmed the conductance can be modulated by six orders of magnitude by transforming the gate voltage. The outcome of the function — a place-temperature transistor produced from one carbon nanotube molecule — were revealed in Mother nature in Could 1998.
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Cees Dekker is Distinguished University Professor at TU Delft. Trained as being a physicist, he pioneered nanotechnology with numerous discoveries on carbon nanotubes within the 1990s. Because 2000, he moved to single-molecule biophysics and nanobiology. His current research https://www.ceesdekker.net concentrates on (i) nanopores for protein sequencing; (ii) chromosome composition, specifically SMC motor protein; and (iii) creating a residing synthetic mobile from lifeless molecules. Dekker can be an elected member of the KNAW and fellow into the APS as well as IOP.
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Case in point (2) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim from the pore is highlighted in pink, as well as a 3D rendering of your motion of your DNA rod is displayed.